Filled Syringe (PFS)
In recent years, various technical innovations were realized and
new methods developed, making the use of pre-filled syringe (PFS)
and cartridge systems much more convenient and attractive.
Measures: Originality seals assure the originality of a product
from its manufacture to its use on the patient. PFS offer several
advantages over traditional packaging in ampoules/vials. A couple
of advantages are ease of use and elimination of several steps that
are required before use of a drug in an ampoule/vial. If the drug
is lyophilized, one of these steps is reconstitution.
of dosing errors: PFS contain the exact deliverable dose desired.
Vials are overfilled by up to 25%, especially if the desired dose
is very small, to ensure that the user may withdraw the desired
dose. This overfill of vials allows the possibility of dosing errors
that are eliminated with PFS. With PFS it is possible to increase
the drug supply and reduce waste. Elimination of the need to overfill
reduces wastage of the product and assures delivery of the complete
assures Delivery of particulate free solution: PFS accommodate
volumes that typically range from 0.25 to 5.0 ml They are therefore
best suited to products administered by subcutaneous or intramuscular
injection. Three categories account for the bulk of PFS: anti-thrombotics,
vaccines and biotech drugs. PFS are aseptic.